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These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia

. Doctors may not be prescribing oral vitamin B12 formulations because they may be unaware of this option or have concerns regarding its effectiveness Objectives: To assess the effects of oral vitamin B 12 versus intramuscular vitamin B 12 for vitamin B 12 deficiency. Selection criteria: Randomized controlled trials (RCTs) comparing the effect of oral versus IM vitamin B 12 for vitamin B 12 deficiency

A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis