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Specifically under conditions of impaired mitochondrial respiration, OCM-derived NADH is no longer consumed through the electron transport chain, thus leading to its aberrant accumulation and toxicity [43,44]

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FIGURE 3 Ferroptosis inhibitors and clinical application Ferroptosis inhibitors eliminate free radicals, inhibiting enzymes that produce lipids or LPOs and reducing free iron

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Metaanalysis of vascular and neoplastic events associated with tamoxifen

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doi: 10.1023/A:1010958512210

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