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Description
The following six asynchronous mutations were found: V12M , Q126X , Q141K , G268R , S441N , and F506SfsX4 (Matsuo et al., 2009)
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13 C NMR (101 MHz, D 2 O, ppm): = 199.9, 174.7, 173.5, 173.4, 172.0, 53.7, 52.8, 41.4, 31.1, 29.9, 29.8, 25.9
Drug therapy aims to alleviate symptoms, enhance functional capacity and prevent exacerbations, but has not shown by randomized trials to reduce mortality or improve quality of life
