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Metabolomic analysis of tumors treated with DRP-104 reveals extensive alterations, indicative of dysregulation in tumor synthetic metabolism and classical cancer metabolic pathways, including changes in glutamine metabolism and reduction in several immunosuppressive metabolites [186]

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In contrast, melatonin therapy demonstrated beneficial outcomes for sleep, cognitive function, depression, and behavioral symptoms in individuals with mild cognitive impairment

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Key points The fate of T cell differentiation can be determined by the activity of various metabolic pathways in the cell, reflecting the central role of metabolism in controlling T cell plasticity

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Yamada, H., Yamamoto, Y

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