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Despite the promising evidence from preclinical models, the effectiveness of HIF1a stabilizers as a future treatment for RA requires careful evaluation due to the pleiotropic and cell-type specific effects of HIF1a in RA pathogenesis

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Pitolisant's efficacy could be mediated through its activity that increases the synthesis and release of histamine in the brain via competitive binding to presynaptic histamine-3 autoreceptors

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