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Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity
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Key outcome measures included the latency to find the platform during training and the time spent in the target quadrant during probe trials, which are indicators of spatial memory retention [2]
Side effects also follow dose-dependent patterns
