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o In September 2025, Rybelsus (oral semaglutide) received an EU label update based on the SOUL trial, making it the first and only oral GLP-1 RA with proven cardiovascular benefits, having demonstrated a 14% reduction in cardiovascular death, heart attack, and stroke in high-risk type 2 diabetes patients

The extracellular matrix proteins decorin, perlecan, and biglycan have all been reported as upregulated targets

Stacking them requires specific caution because GLP-1 drugs alter gastric motility, insulin signaling, and appetite regulation

For beginners, starting with evening application allows your skin to adjust without the added stress of UV radiation and environmental pollutants