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Given the significant remodeling of the ECM and its central role in both primary tumors and metastases, future studies into its precise function could lead to new insights and treatment strategies

The findings of increased oxidant stress related to decreased expression of Nrf2 in kidney cells suggests that direct binding of the mycotoxin to DNA is not needed to create DNA damage [79]

These include dependence on operator skills, challenges in image interpretation, limitations in the availability of acoustic windows, and issues with resolution and specificity

61,62,63,64,65,66 Astrocyte reactivity phenotypes can at present be broadly classified into two major categories of (i) non-proliferative astrogliosis, which is isomorphic with mainly preserved domain organisation