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The purpose of the current investigation was to evaluate whether acute L-carnitine and carbohydrate intake alters respiratory exchange ratio (RER), blood lactate, power output, and time to exhaustion during 40 minutes of cycling at 65% of VO 2peak , followed by cycling to exhaustion at 85% of VO 2peak

( a, b ) HepG2 cells were treated with LC (10 mM) and Buty (1 mM) for 12 h

According to the energy starvation hypothesis, which induces that insufficient ATP supply underlies the contractile dysfunction presenting in heart failure [34], it seems reasonable that L-C improves energy metabolism in cardiomyocytes, which may finally translate into mechanical efficiency and contribute to the improvement of clinical symptoms and cardiac function