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Because the observed toxicities were not directly correlated with mitragynine concentration, these effects may have been due to a toxic build-up of O -desmethyltramadol and/or other unknown opioids as part of the multidrug exposure

10.1111/odi.13727 211

Methods Rats and surgical procedures All studies were carried out in accordance with the NIH Guide for the Care and Use of Laboratory Animals (NIH Publication No

Based on historical data, attachment loss improved by 2.0 mm 6 months after surgery alone, while improvement reached 3.4 mm following DPSC injection, with a standard deviation of 1.7 mm
