glutathione reductase peroxidase kit Total Assay (100 tests) ensuring smooth and accurate processing Glutathione Peroxidase 4 GPX4 Activity

Kuzminski, A

Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells

Nature Reviews Endocrinology, 19(6), 345-360.

Thus, GPx4 activity is a central molecular switch in the ferroptosis pathway, and the System XcGSH-GPx4 axis is also a central pathway in the ferroptosis pathway, in which a key member, inhibitory SLC7A11 (solute carrier family 7 member 11), inactivates GPx4 and increases lethal reactive oxygen species by blocking the entry of cysteine into the cell, thereby reducing GSH synthesis and ultimately inducing ferroptosis