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In contrast, similar experiments in breast cancer MCF7 cells revealed only modest effects on platinum sensitivity (Peklak-Scott et al, 2008), while partial GSTP1 knockdown in the adriamycin-resistant human colorectal cancer cell line M7609 increased sensitivity not only to the selection agent, but to cisplatin, melphalan and etoposide (Ban et al, 1996)

The different cell death pathways in cancers provide useful targets for cancer treatment

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The Notch pathway, which governs neural stem cell proliferation and differentiation, can be inhibited by MSCs to promote neuron differentiation