structure of glutathione
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Description
Kneeshaw, S
& Sharma, J
During ageing, mtDNA, Tfam, ROS, ATP, cardiolipin, and N-formyl peptide can be released as DAMPs and are recognized by pattern recognition receptors upon mitochondrial stress or compromise, leading to the activation of MiDAS and SASP
In addition, heterozygous D3KO mice are more vulnerable to isoproterenol, further worsening the restrictive cardiomyopathy and leading to congestive heart failure and increased mortality (155)
