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According to the Federal Office of Consumer Protection and Food Safety, the daily intake of dietary supplements in tablet form must not exceed 50 mg of methylsulfonylmethane, based on a recommended daily intake of one tablet. Children and adolescents, pregnant and breastfeeding women, and patients being treated with coumarin anticoagulants should refrain from taking the supplement. Little is known about possible side effects and the consequences of overdoses

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Figure 1 shows that fecal water content in aging rats with FC was significantly increased, prompting the examination of aquaporin (AQP) levels related to water reabsorption in intestinal contents