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10.1186/s13287-020-01914-1 23 GurevichI.BurtonS
It is recommended to conduct double-blind RCTs that adhere to stringent standards, including robust randomization procedures, proper allocation concealment, effective blinding techniques, and meticulous handling of missing data [206]
Several animal studies indicate that MPs reduce gut microbial diversity and shift the dominant phylum ratioparticularly elevating the Firmicutes-to-Bacteroidetes (F/B) ratiowhile depleting beneficial genera like Bifidobacterium and enriching opportunistic pathogens like Staphylococcus 31,36,77
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