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Many possible oxidative stress markers have been discovered in ASD, however, attempts to monitor the oxidative stress status of children with ASD are still difficult to meet clinical application standards, and additional study is needed

Plasma cGMP levels were measured as indicators of the actions of endogenous nitric oxide, and the GPx-3 mice had markedly lower levels of cGMP

Clinicians should reassess efficacy at monthly intervals and consider tapering after sustained symptom improvement to mitigate potential receptor down-regulation

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