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We assigned the carboxyl terminal (C-terminal) loop (C-loop) to face the cytosol and the amino terminal loop (N-loop) to face ER lumen according to the enriched positively charged residues at the C-terminal side 33 (Extended Data Fig

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The esophageal microbiota in esophageal adenocarcinoma patients has shifted toward an increased prevalence of gram-negative bacteria, such as Prevotella intermedia and E