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Reduced glutathione, the active form of this antioxidant, becomes oxidized, deactivated, during its antioxidant activity, thus, requiring reduction through glutathione reductase to regain its antioxidant activity

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Furthermore, nicotinamide adenine dinucleotide phosphate (NADPH), derived from niacin, is crucial in antioxidant defense mechanisms, by aiding in the regeneration of other antioxidants, such as glutathione (51)