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Measures of physical function, body composition, blood pressure, and lipids were compared between 3 cohorts at baseline, change in response at 16-weeks versus baseline among OAP and OAG, 16-week OAP/OAG versus YA at baseline, and OAP versus OAG at 16-weeks (8 tests per measure)

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McEwens study represents one of the first efforts to achieve a precision medicine approach that treats the sub-types of depression, a major goal of the Depression Task Force since it was created in 2010