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In Clostridioides difficile infection (CDI) colitis models, IL-25 expression is suppressed, and IL-25 supplementation restores eosinophil numbers and reduces mucosal injurydespite no changes in bacterial burden or toxin levels (29, 30)

And this then could have led to gut leakiness

Goshajinkigan Reduces Oxaliplatin-Induced Peripheral Neuropathy without Affecting Anti-Tumour Efficacy in Rodents
