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These should include: (1) Examination of these processes at different stages of the disease, (2) mechanistic studies to pinpoint signaling pathways involved in the regulation of the oxidative stress and DNA damage response markers and (3) studies addressing whether the deficits reported here can be reverted with antioxidant treatments

C-Met as a key factor responsible for sustaining undifferentiated phenotype and therapy resistance in renal carcinomas

Each component was selected for its distinct mechanism of action, creating a multi-pathway approach to tissue repair research