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Related experiments have confirmed that HO-1 effectively inhibits IkB phosphorylation and its subsequent degradation, leading to NF-B translocation and downstream inflammatory gene transcription reduction, which indicates that CGA activates Nrf2/HO-1 and inhibit NF-B (52)

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression
