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The idea that you could harness this signaling machinery and point it at specific problems is scientifically compelling

Current gene therapy research aims to target, for example, upstream targets of the GSH system or molecules associated with it (such as Nrf2, GPX, SLC7A11), genes aberrantly expressed in myocardial injury, and noncoding RNAs regulating mRNA transcription [76, 202, 250253]

For instance, melatonin receptors and eventually their signaling was significantly upregulated by the HDAC inhibitors via histone acetylation (Prokopenko et al., 2009)