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Subacute lipid peroxidation cascades trigger ferroptosis and microglial polarization, whereas chronic-phase recovery of executive networks is scaffolded by sirtuin-mediated mitochondrial biogenesis and the interplay between adenosine monophosphate-activated protein kinase (AMPK) and mechanistic target of rapamycin (mTOR)

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As interest in NNMT-related mechanisms grows, 5-Amino-1MQ remains one of the most compelling small-molecule metabolic agents under investigation
