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Description
Development was discontinued because the Phase IIb trial of 536 subjects over 24 weeks failed to meet its primary efficacy endpoint
Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)
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This guide documents a research protocol
