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It is defined as the volume of voids that can contain liquid or air in relation to the total volume of the material 33

A total of 68 articles were included in the final synthesis (corresponding to the reference list), comprising clinical trials and observational studies of GLP-1RA, mechanistic and immunology papers on GLP-1 signaling and metabolic inflammation, literature on autoimmune thyroid disease pathophysiology, adipokines, Non-alcoholic fatty liver disease (NAFLD)/Metabolic dysfunction-associated fatty liver disease (MAFLD)/Metabolic dysfunction-associated steatotic liver disease (MASLD)/Metabolic dysfunction-associated steatohepatitis (MASH), and gut-thyroid-microbiota interactions

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We also found the increased reaction fluxes for succinate and itaconate in the TCA cycle which act as the signaling molecules for inflammatory responses during M1 phenotype 30,31