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Since NRF2 activation induces the antioxidant and detoxifying response to restore redox homeostasis state, in recent years there has been a growing interest in identifying and evaluating new compounds capable of targeting the KEAP1-NRF2 system, to induce cytoprotective response against OS

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By 2016, comprehensive reviews had systematically catalogued major targets and representative molecules, marking a transition from the conceptual stage toward structured development and therapeutic exploration [30]

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