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The Neh1 domain contains a bZIP binding motif responsible for the formation of a heterodimer with small musculoaponeurotic fibrosarcoma (sMaf) proteins and mediates the binding to ARE sequences, within the promoter of NRF2 target genes [152]

Additionally, we primarily focus on the duration of GSH intake, without examining the effect of specific dosage on the prognosis of breast cancer patients undergoing chemotherapy

Iron regulatory proteins (IRPs), bind to iron-responsive elements (IREs) in the 5 untranslated region (UTR) of mRNAs encoding ferritin and FPN1 to inhibit their translation, while binding to IREs in the 3 UTR of TfR1 and DMT1 mRNAs to stabilize these transcripts, thereby adjusting iron storage, export, and uptake (58)

Unbiased analysis of all the significant protein hits with FC \(\ge \)0.8 (log 2 ) using metascape.org platform 54 , revealed top enriched ontology terms for categories including Cellular Component, Biological Processes and CORUM (Supplementary Fig