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Description
By increasing NAD levels and activating the SIRT1 pathway, NNMTi inhibits the activation of inflammatory signaling pathways (such as the NFB pathway), thereby reducing macrophage infiltration and inflammatory factor release

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Cyanocobalamin dose for dogs is generally used in dogs with known or suspected deficiency, and those with chronic gastrointestinal (GI) disease, exocrine pancreatic insufficiency (EPI), intestinal dysbiosis, inflammatory bowel disease (IBD), malabsorption disease, severe malnutrition, or some inherited conditions that affect vitamin B12 absorption

Subcutaneous administration at 50mg produces approximately 4050% NNMT enzyme inhibition, while 100mg achieves 6075% inhibition