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If a severe allergic reaction does occur, it will usually be within 20 - 30 minutes of giving the injection and the most common sign is collapse

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IV infusion (clinic-based) Protocol: Continuous daily supplementation -- typically 250-1000 mg NMN or 300-600 mg NR per day Rationale: NAD+ depletion is continuous, requiring ongoing replenishment to maintain elevated levels Requirements: No special handling for oral supplements

J Enzyme Inhib Med Chem 32(1):193202 Youdim MB, Edmondson D, Tipton KF (2006) The therapeutic potential of monoamine oxidase inhibitors