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NAC has been used safely during pregnancy in clinical settings (e.g., for acetaminophen overdose) and in some research trials for PCOS and recurrent pregnancy loss
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Examples of drugs that exhibit flow dependent hepatic clearance (high hepatic extraction ratio) include: Morphine , Lidocaine, Verapamil, Nitroglycerin, Propranalol Flow-Dependent Clearance The clearance of high-extraction drugs is primarily dependent on hepatic blood flow
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