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The current experimental data indicate glucocorticoids have direct effects on the endothelium, and depending on the context these effects may be beneficial (e.g., infection) or detrimental (e.g., hypertension associated with chronically elevated levels of glucocorticoids)

*Correspondence: Jialing Hu, [email protected] Li, [email protected] Mei, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged