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The left protein is a form that is kinetically trapped during heterologous expression
The hormonal environment is working against them
Only with the recent development of locus-targeted tools, such as clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) or transcription activator-like effector nucleases-based epigenetic editors, has it become feasible to directly test how defined chromatin or methylation changes influence neural and behavioral outcomes 9,183,184
Nature 563 , 354359 (2018)
