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doi: 10.1074/jbc.M205670200 561 GuerraJDevesaJ
It should be noted that a related molecule, ()-physostigmine (5), can cross the bloodbrain barrier

Non-invasive alternatives include inhaled or oral insulin

Even in the absence of major depression, bupropion might help those who experience fatigue along with brain fog or daytime sleepiness (sometimes sequelae of chemotherapy or long-term endocrine therapy)
