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The data indicate that contraction activated PGC-1 signaling pathways in skeletal muscle are redox-sensitive and that non-mitochondrial ROS play an important role in stimulating mitochondrial biogenesis

At the same time, iron overload leads to the upregulation of HO-1 and a massive breakdown of heme (hemoglobin) [35]
H., Folseraas, T., Thorburn, D
doi: 10.1096/fsb2fasebj.12.1.57 162 GruenMLHaoMPistonDWHastyAH
