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In the inner ear, the auditory organ houses mechanosensitive hair cells required for translating sound vibration to electric impulses

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From a GABAergic perspective, the neuroprotective role of CX3CL1 could be attributed in part to enhanced inhibitory currents and suppressed AMPA receptor function during the acute excitotoxic phase of ischemia (Cipriani et al., Studies on both physiological and pathological conditions, such as epilepsy, demonstrate that the CX3CR1 pathway may regulate the number of post-synaptic GABA A receptors or their sensitivity to GABA and thus their subunit composition (Heinisch and Kirby, 2009