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284 Disintegration of glia limitans translates into the widespread damage to the bloodbrain barrier and degranulation of natural killer cells that release perforins and granzyme, which in turn, further injure astrocytes and endothelium

Izumi H, Cairney JWG, Killham K, Moore E, Alexander IJ, Anderson IC

Abstract Glutathione, a vital antioxidant, is often limited by its rapid degradation in the gastrointestinal tract

for example, in patients with gliomas, methylation of the promoter of the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is a problem in cancer therapy with alkylating agents [139] (Table 2)