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Ziziphus Spina-Christi Leaves Methanolic Extract Alleviates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats
Emerging strategies to increase the bioavailability and therapeutic efficacy of phytochemicals in cancer therapy Phytochemicals have high anticancer effects that are multi-targeted, regulating the activation of the PI3K/Akt, MAPK, and NF-kB signaling pathways, yet their use in the clinic is impacted by low aqueous solubility, chemical instability, low membrane permeability, and rapid metabolism [175, 309]
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