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The neurological aspects of the disease are thought to arise from the accumulation of methylmalonyl- CoA due to the requirement of B 12 as a cofactor to the enzyme methylmalonyl-CoA mutase

They also improve comfort and reduce treatment times

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Early data from amycretin showed up to 13.1% weight loss in just 36 weeks of a phase 1/2 trial, with the weight loss curve still descending steeply