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If you dont have healthy bile composition or bile flow, you may end up with: Vitamin D and K deficiencies which may affect bone health Vitamin D and A deficiencies which may affect immune health Vitamin E deficiency and lower antioxidants Increased dietary oxalate absorption, which may cause mineral deficiencies such as zinc, magnesium, and iron 14 Deficiencies in these minerals have their own set of consequences Constipation Fatty liver High cholesterol Sleep issues Poor detoxification Symptoms of excess estrogen such as PMS, PCOS, or endometriosis SIBO 3,6 Acid reflux that doesnt improve with antacids is typically bile reflux Increased risk of gallstones Gallbladder Dysfunction Increases SIBO Risk The small intestine is typically not home to many microbes

Vitamin B12 deficiency can result in malformed and large red blood cells, known as megaloblastic anemia

It may be necessary to attack each of these likely causes with separate drug development programs

The detailed SAR trends are provided in Supplementary Tables S2, S3