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On the other hand, during the process of reactive astrogliosis, astrocytes release inflammatory cytokines that may affect the surrounding neurons, both by the induced production of ROS and lipid peroxidation, and by the activation of apoptotic mechanisms that induce neuronal dopaminergic death [6,10]

This receptor modulation triggers a cascade of intracellular signaling events that ultimately result in the activation of hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids and glycerol