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Since 24 h treatment of adipocytes with an NNMT inhibitor increased intracellular levels of SAM and NAD + , it is likely that prolonged exposures to NNMT inhibitor during differentiation may have resulted in significantly enhanced intracellular flux of SAM and NAD +
This is an immediate treatment with no down-time required
[2] Risk factors may occur possibly more in elderly people due to impaired intestinal absorption, and in children, premenopausal women, and pregnant women, whose diets are low in animal foods
The clinical scenarios on the next page provide some clarification
