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FAC has low toxicity but has been shown to sensitize HT-1080 fibrosarcoma cells to erastin-induced ferroptosis (Figure 1, FAC does not induce cell death in normal human fibroblasts at concentrations up to 1.2 mM

Compared to other amino acids, methionine has a limited range of functionalities

Furthermore, DAG generated by PNPLA2 preferentially produces 1,3- DAG which cannot activate PKC (196), suggesting that the de novo generation of DAGs leads to insulin resistance

The direct influence of the E4 allele on FA-related bioenergetics (i.e., the transport and use of metabolites, in this case FAs, for energy) within the cerebrovasculature requires further attention, specifically in E4 carriers because of their increased cerebrovascular vulnerability observed with age which could impair nutrient transport to the brain and affect proper neuronal and glial functioning (Ojo et al., 2021)