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And perhaps most important, was the test done at a time where the gastrointestinal tract still suffered from lack of B12, and because of that had a temporary decreased capacity for uptake of B12

This experiment confirmed that the product can delay systemic aging by regulating NAD+ metabolism, providing in vivo evidence for anti-aging interventions

Food and Drug Administration: Glucophage (Metformin Hydrochloride) Tablets Label JCEM Case Reports : Metformin-Associated Vitamin B12 Deficiency: An Underrecognized Complication Clinical Diabetes : Increasing Vitamin B12 Screening Among Patients With Type 2 Diabetes on Long-Term Metformin Therapy Harvard Health Publishing: Vitamin B12 Deficiency Can Be Sneaky and Harmful Johns Hopkins Medicine: Vitamin B12 Deficiency Anemia Yale Medicine: Are You Getting Enough Vitamin B12

It activates 3-adrenergic receptors in adipose tissue and stimulates fatty acid oxidation
