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The manufacturer of OPITAC glutathione, the Japanese company KOHJIN Life Sciences, a wholly owned subsidiary of Mitsubishi Corporation Life Sciences, was one of the first laboratories to draw attention to the importance of L-glutathione back in the 1960s, when it was first demonstrated benefits compared to the "first line of defense" against the harmful effects of toxins, including environmental pollutants, on the body

Antimicrobial effectiveness was evaluated using culture-based enumeration, while CAP-induced cellular damage was assessed using scanning electron microscopy (SEM), and assays measuring lipid peroxidation, reactive oxygen species accumulation, membrane permeability and malate dehydrogenase activity

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