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For instance, albiglutide (73.0 kDa) is composed of two copies of a modified GLP-1 (residues 736) fused in tandem to the N-terminal end of wild-type (WT) human albumin 10,28

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Discrepancy between amylin receptor binding affinity and receptor activation This study found multiple mutations that enhanced peptide ligand affinity for amylin and calcitonin receptor ECDs by over 100-fold (Figure 7, 8, and Table 2)