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Patient 2 started receiving methotrexate at a significantly higher level than the other patients, and their weight-based dose was equivalent to 13.4 units/kg of glucarpidase

Oncotarget 6 , 4065540666 (2015)

Hence, the safety associated with copper delivery through the skin needs to be established

Additionally, in patients with thick nasal skin post-rhinoplasty, isotretinoin may enhance early cosmetic outcomes, although its long-term aesthetic benefits appear limited
