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6.4 Oxidative stress Oxidative stress plays a critical role in hypertension due to the fundamental roles of ROS and redox signaling in molecular, cellular, and systemic processes that contribute to endothelial injury, vascular dysfunction, cardiovascular remodeling, renal impairment, sympathetic nervous system excitation, immune cell activation, and systemic inflammationkey factors in the pathophysiology of hypertension [240, 241]

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Footnotes Online address: DISCLOSURE A Dunne, A Cerami and M Brines are employees of Araim Pharmaceuticals and have stock or stock options in the company

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