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13 In contrast, it was recognized that the binding to mitochondrial proteins after APAP overdose correlated with toxicity, 14 suggesting that mitochondria could be a critical target

Therefore, the differentiation and maturation of osteoclasts from precursor cells are supposed to be suppressed by IS, and whether or not these are dependent on the effects of RANKL and MCSF needs further investigation

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Based on the findings, the appropriate functionalisation of thiosemicarbazone may be improved the inhibitory activity of these inhibitors