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These studies mark the first administration of a drug candidate to human subjects and provide the initial clinical evidence needed to guide subsequent phases of development

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Secondly, therapeutic heterogeneity: clinical trials exhibit marked heterogeneity, such as the efficacy of probiotics or prebiotics being influenced by the baseline microbiota of host, diabetic duration, and glycemic control, while the scarcity of large-scale, multicenter RCT data hinders the establishment of uniform treatment standards

Recent literature has expanded the research surface for the parent T4 to candidate roles in kidney disease (Di et al